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利用氨基磺酸良好的催化性能可以达到什么效果?
来源:http://www.jnjrh.com 日期:2019-06-21 发布人:admin
应用氨基磺酸良好的催化性能,合成了4种不同体系的化合物超越80个,经过熔点,红外,核磁,元素剖析等手腕确认了却构。挑选出适宜的溶剂,调查了反响温度,时间,反响物配比等对产率的影响,并讨论了反响的机理。实验结果如下:
With good catalytic performance of sulfamic acid, more than 80 compounds of four different systems were synthesized. Their structures were confirmed by melting point, infrared, nuclear magnetic resonance and elemental analysis. The effects of reaction temperature, time and the ratio of reactants on the yield were investigated, and the mechanism of reaction was discussed. The experimental results are as follows:
氨基磺酸良好的催化性能
Good Catalytic Performance of Aminosulfonic Acid
1. 以易得的芳香醛为起始物,经过经典的安息香缩合反响制得a-羟基酮,再经过氧化得到对称二酮,最后与邻苯二胺或取代邻苯二胺反响得到喹嗯啉衍生物。最适溶剂为二氯甲烷。经过正交实验得到的优化条件为: n(二酮): n(二胺):n(氨基磺酸)=1:1:0.15,反响温度25。C,反响时间6h.氨基磺酸在循环使5次后,产率稍微降低。
1. Using aromatic aldehydes as starting materials, a-hydroxyketone was synthesized by classical benzoin condensation reaction, then symmetrical Dione was obtained by oxidation, and finally quinoline derivatives were obtained by reacting with o-phenylenediamine or substituted o-phenylenediamine. The optimum solvent is dichloromethane. The optimum conditions obtained by orthogonal experiments are: n(diketone):n(diamine):n(aminosulfonic acid)=1:1:0.15, and the reaction temperature is 25. C. The reaction time is 6h. The yield of aminosulfonic acid decreases slightly after 5 cycles.
氨基磺酸
2.以氨基磺酸作催化剂, 不管是芳香酮、环己酮或是3-戊酮,与芳香醛和芳香胺的三组分Mannich反响均能够顺利停止得到B-氨基酮。经过优化,得到三组分以及催化剂用量的最佳摩尔比为1:1:1:0.1, 30。C为较理想的反响温度,乙醇作溶剂是最好的选择。
2. Using sulfamic acid as catalyst, whether aromatic ketone, cyclohexanone or 3-pentanone, the Mannich reaction with aromatic aldehydes and aromatic amines can stop to obtain B-aminone smoothly. After optimization, the optimum molar ratio of three components and catalyst dosage was 1:1:1:0.1, 30. C is an ideal reaction temperature, and ethanol as solvent is the best choice.
3.以氨基磺酸作为酸催化剂, 在无溶剂室温条件下,羰基化合物、芳香胺及亚磷酸二乙酯-锅法合成了多个a-氨基膦酸酯。苯甲醛对位若有吸电子基团,产率很高。
3. Aminophosphonates were synthesized by carbonyl compounds, aromatic amines and diethyl phosphite-pot method using sulfamic acid as acid catalyst at room temperature without solvent. The yield of benzaldehyde is very high if there are electron-withdrawing groups in the para-position of benzaldehyde.
4.以醛、邻苯二胺为原料,在氨基磺酸的催化下,室温下合成苯并咪唑衍生物。以芳香醛和杂环醛为原料都能够顺利地生成目的产物,但脂肪醛参与反响的时分,反响产物较多,不易别离纯化得到目的物。采用同样的反响条件,醛与邻苯二胺摩尔比为2: 1时能够得到1,2-二取代产物: 2-芳基-1-芳基甲基-1H-1,3-苯并咪唑。
4. Benzimidazole derivatives were synthesized from aldehyde and o-phenylenediamine under the catalysis of aminosulfonic acid at room temperature. Aromatic aldehydes and heterocyclic aldehydes can be used as raw materials to produce target products smoothly, but when aliphatic aldehydes participate in the reaction, there are many reaction products, so it is not easy to separate and purify the target products. Under the same reaction conditions, when the molar ratio of aldehyde to o-phenylenediamine is 2:1, 1,2-disubstituted product: 2-aryl-1-aryl methyl-1H-1,3-benzimidazole can be obtained.
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相关标签:氨基磺酸